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Episode 17Life's DignityBlack Jack tells Dr. White to change course to the North Pole, meanwhile Renka start her plan in getting the Phoenix Disease. Later the Sky Hospital receives a call from the US Alaska base, and are told that Doctors from all the world are trying to find the cure to the Phoenix Disease, one of them being Dr. Kuma revealing that they only have 21 hours to cure or die. The National Security manager is told that they are going to launch a Nuclear Missile to rid of the Virus and as well of those ill from it. Renka gets on the Sky Hospital. Just before Renka about to shot Black Jack, her father interfere, they both shot each other, Zen Mantoku died and Renka injured badly, Black Jack decided to operate Renka, anyway. When operating Renka Black Jack finds the cure to the Phoenix Disease. The missile has been shot without any way to making it to don't crash on North Pole. While the Phoenix Disease continues to spread in Black Jack's body, he questions himself why he is saving Renka's life. He sees Benitokage, Dr. Kiriko, Dr. Honma, and his parents telling him that he did enough until he sees Pinoko in a 18 years old form telling him that the patients are waiting. The Antiserum is named Honma Antiserum . Finally Black Jack & Pinoko return with their friends, after dealing with the most dangerous "enemy" yet.
Episode 16Challenge to DestructionBlack Jack is ready to go Japan with Pinoko when is requested to go to the Sky Hospital and check on Zen Mantoku who has Phoenix Disease, by a direct request of Dr. White & Renka. Black Jack agrees in performing the operation with Dr. White. Renka secretly plots to get the Disease cure so she can win much money when she spreades Phoenix disease. One of Renka's henchmen tries to hijack the Hospital and by that Mantoku gets out of the Capsule causing the Phoenix Disease to spread among the aircraft. Now Black Jack has to face the Phoenix Disease to save Pinoko and the others lives.
Episode 15Truth about BJ's FatherBlack Jack is called by Renka, he thinks that about his father but she says she want him to stay and be a family, but Renka's daughter thinks Black Jack is after his father's fortune. When about operating on his father, the organization henchmen kidnap Pinoko and lure him in a trap, in which he gives up the pendant. Benitokage appears and saves the day, apparently because one of the Organization knocks Black Jack and then he awakes to meet Zen Mantoku the former leader. He tells that the reason of his father to leave Black Jack and his mother was to protect them from the Organization (meaning the bomb that near killed Black Jack was a plot of the organization) it is revealed who Benitokage is, and then both of them work together to escape. At the end Black Jack is aimed with a Sniper Rifle in which Benitokage saves his life using her.
Episode 14The Terrifying Phoenix DiseaseBlack Jack and Pinoko arrive into Okonja Village on a helicopter. However, many villagers have already died from various diseases. Black Jack persuades the reluctant pilot to fly further towards Arnol Village.
Episode 13Pinoko, Go Back to Japan!Black Jack and Pinoko run into Sharaku when they arrive in Africa. They meet a boy named Al.
Episode 12Beyond the AuroraBlack Jack is now in Canada. He goes into the mountains to find Dr. Jorujyu's research lab. The Lady that has been trying to kill him was injured and he decided to helper. An avalanche suddenly happens and traps all three of them in the cellar. The document that he finally finds, that was about the phoenix disease, ends up being lost in the snow.
Episode 11The Destiny of the Black DoctorBlack Jack arrives at the cottege that Dr. Jorujyu was living in but gets shot at by the Dr's daughter. The brother was out to kill the Dr. But does not succeed. Dr. Jorujyu has the phoenix disease and dies from it.
Episode 10A Miracle in New YorkBlack Jack is alive because his mother, Mio's pendant stopped the bullet from hitting him. He operates on the doctor's mother and discovers a Type Hydra artificial heart. It is a heart that keeps on pumping even when it is extracted from the host. They replaced the Type Hydra with another artificial heart that Black Jack requested and saved her life. They discover that the Type Hydra was designed by Hazama Kagemitsu, Black Jack's father through a microfiche that was inside Mio's pendant. The doctor's mother tells Black Jack how his parents met and how she got the artificial heart.
Episode 9The Imprint on the HeartBlack Jack and Pinoko travel to New York. A doctor who happens to be the son of an old friend of Black Jack's parents, asks Black Jack to help him operate on his mother because she has Honma's Hematoma. Black Jack, remembering his mentor's words not to get involved in that disease, refuses. Later, Black Jack discovers the clock that was in the photo he found. Benitokage shows up and shoots Black Jack in the heart.
Episode 8Awake After Sixty-Five YearsBlack Jack finally arrives in England to hear of a man who's been in a coma, unaged, for 65 years. Dr. Stein wants to analyse him to find out why he hasn't aged, thinking it will give them information about eternal youth; but the patient's niece has hired Kiriko to put an end to it. Black Jack operates, but afterwards the patient ages and dies upon finding out that his family had died.