Cursed Blood
After the Schiff's attack, Saya agrees to share her blood with Irene. After drinking her blood, Irene's body crystallizes and shatters. The Schiff realize that they have been lied to and that it is Diva's blood they need to survive. They leave, taking most of Irene's pieces with them. Saya and Kai mourn Irene's death.
Aired 29/04/2006EP 29 - Cursed Blood

Blood+
Saya Otonashi, a seemingly normal high school student, suffers from amnesia and she can't remember the past year of her life. One day, after a man appears and gives her a katana sword, her destiny begins to be revealed.
Soon she finds herself fighting the latest threat to humanity - Chiropteran monsters, ravenous immortal creatures that can change their form, disguising themselves as human beings. They feed off blood and hide themselves within the human world. An organization known as the Red Shield has been waging a private war to wipe them out and now the struggle has grown. Saya's journey for the truth has begun.
(Source: Sony Pictures Home Entertainment)