The Secret of the Frog with a Navel
Because Totoo was originally a human, he has a navel even though he is now a frog. Finding out that a frog with a navel is living on a Southern island, Melmo and the party head there. On the island, a masked woman is giving villagers pollen as a medicine to make them regain their youth. Prof. Waregarasu, who accompanies the party, sees that the pollen contains narcotics. The navel of a frog is proven to be a stomach wart caused by narcotics. Melmo and the party decide to stick stamens to the pistil of a giant flower blooming on the top of the mountain. If they succeed in fertilizing to the seed, the flower will wither. Source: tezukaosamu.net
Aired 05/12/1971EP 10 - The Secret of the Frog with a Navel

Fushigi na Melmo
After nine-year-old Melmo loses her mother in a car accident, she is left to care for her two younger brothers, a task far beyond her age or means. However, in the midst of her grieving, Melmo is visited by the ghost of her deceased mother who gives her a bottle of miraculous candy, capable of transforming her into either an adult (blue candy) or an infant (red candy). A combination of the two can reduce her to a fetus and then change her into any animal she imagines. Drawing on a seemingly inexhaustable supply, Melmo uses her candies to solve the various problems thrown her way, aided by her younger brother Toto (who accidentally morphs into a frog in episode 7) and her cantankerous mentor, Dr Nosehairs.
(Source: Anime News Network)