A Night at the Mansion of the Lizard
Having taking away the bottle of candies, Melmo's brother, Totoo, keeps teasing her and won't give it back. Melmo tries to make him return it, but Totoo won't give it to her. Melmo decides to teach him how to use the candies to turn into an animal. She plans to get the bottle of candies back while Totoo is in the form of an animal. Totoo then turns into a frog. Melmo is now in trouble, because a frog cannot eat the candy when she wants to turn him back into Totoo. And it can't even take the water that she could dissolve the candies into. Source: tezukaosamu.net
Aired 14/11/1971EP 7 - A Night at the Mansion of the Lizard

Fushigi na Melmo
After nine-year-old Melmo loses her mother in a car accident, she is left to care for her two younger brothers, a task far beyond her age or means. However, in the midst of her grieving, Melmo is visited by the ghost of her deceased mother who gives her a bottle of miraculous candy, capable of transforming her into either an adult (blue candy) or an infant (red candy). A combination of the two can reduce her to a fetus and then change her into any animal she imagines. Drawing on a seemingly inexhaustable supply, Melmo uses her candies to solve the various problems thrown her way, aided by her younger brother Toto (who accidentally morphs into a frog in episode 7) and her cantankerous mentor, Dr Nosehairs.
(Source: Anime News Network)